Scrubsfeatures plenty of hospital romances, but many of the cast members have found love in their own lives.
The heartfelt medical sitcom — which aired from 2001 until 2010 and was rebooted in February 2026 — follows the lives of a group of doctors who work in a hospital, primarily through the perspective of J.D. (Zach Braff). He gets through his days with the help of best friends Turk (Donald Faison), Carla Espinosa (Judy Reyes) and Elliot Reid (Sarah Chalke), all while trying to perform under intense pressure from his superiors Dr. Kelso (Ken Jenkins) and Dr. Cox (John C. McGinley).
While Braff is currently single, he ended up helping his costar, Faison, find love: Faison met his future wife, CaCee Cobb, at Braff's 30th birthday party in 2005. The two got engaged in 2011 and married at Braff's home in 2012, where Braff served as a groomsman.
Here's everything to know about the real-life loves of theScrubscast.
Zach Braff
Though his character has been on-and-off coupled up with Elliot (Chalke) inScrubsfor years, Braff is currently single.
The actor has had a few high-profile romances. He was in a relationship withMandy Moorefrom 2004 to 2006 and model Taylor Bagley from 2009 to 2014. Most recently, hedated Florence Pughfrom 2019 until 2022 after first connecting on social media.
However, Faison wants to change Braff's single status. "This is a single man who is very, very handsome," Faison told PEOPLE in December 2025 for the Sexiest Man Alive issue. "Someone out there is going to see this [issue] and be like, 'What a handsome young man this is!' "
In a potential partner, Braff said he's looking for attraction and banter. "I mean obviously there's the initial 'Am I attracted to this person?' " he said. "But then I'm so aware that for me now it's being funny and laughing with the person. To me that's the sexiest thing. Beyond the initial 'Oh you're cute,' is 'Do we laugh?' "
Donald Faison and CaCee Cobb
OnScrubs, Faison plays J.D.'s best friend, but in real life, Braff played a part in Faison meeting his wife. Faison and Cobb met at Braff's 30th birthday party in 2005 and got engaged in 2011 before marrying in 2012 at Braff's home.
Braff served as a groomsman, while one of the bridesmaids wasJessica Simpson, whom Cobb once worked for. Since then, Faison and Cobb have welcomed two children together: Rocco, born in 2013, and Wilder Francis, born in 2015. Faison is also a dad to four children from previous relationships: sons Sean and Kobe and twins Dade and Kaya.
In September 2019, Faison has told PEOPLE that he loves being a father, but he misses "being able to go anywhere I wanted to go with my wife and not [having] to worry about a babysitter."
Judy Reyes and George Valencia
Reyes' Carla Espinosa ends up marrying Turk onScrubs, but her real-life love story is different. She's in a long-term relationship with directorGeorge Valencia. They have one child together named Rey, whom they welcomed on Nov. 27, 2009.
The couple co-founded the nonprofit organization Sound of Gol Foundation. Valencia toldThe Guardianin October 2024 that their mission is to "educate and empower the Latina woman, so they can educate and empower the Latina girl."
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The Hollywood couple still finds time to celebrate each other. When wishing Valencia a happy 50th birthday in December 2022, Reyes shared a photo of him in sunglasses on Instagram.
"Happy 50th to my ride or die, my right hand man, my baby daddy, the love of my life, my best friend. I love you G$. ♥️🤎♥️🤎," Reyes wrote in thecaption.
Sarah Chalke
Chalke was engaged to Jamie Afifi for more than a decadebefore their 2022 split.
Afifi popped the question in 2006, and the two remained engaged until 2022, when a rep for Chalke told PEOPLE that they'd "separated some time ago." During their relationship, they welcomed two children: Charlie, born on Dec. 24, 2009, and Frances, born on April 28, 2016.
Ken Jenkins and Katharine Houghton
Jenkins may be known for playing the hard-nosed chief of medicine Dr. Bob Kelso, but in his personal life, he goes by "husband" for actress and playwrightKatharine Houghton.
Jenkins has been married to Houghton since 1970. He has three children from a previous marriage, includingTony Award-nominated actor Daniel Jenkins.
Houghton has been a successful actress for decades, earning a 1967Golden Globe Awardnomination for her performance as Joanna "Joey" Drayton inGuess Who's Coming to Dinneralongside her aunt,Katharine Hepburn.
John C. McGinley and Nichole McGinley
McGinley portrays the sarcastic, cynical and unwilling mentor to J.D., Dr. Perry Cox, who's "married but not married" to the equally sardonic Jordan Sullivan (Christa Miller). In reality, John is married to yoga teacher and birthing doula Nichole McGinley.
The couple first met in 2004— all thanks to McGinley's son, Max. McGinley and his ex, Lauren Lambert, welcomed Max, who has Down syndrome, on Aug. 31, 1997.
"I come back [to the beach] and Max is sitting in this lady's lap and I'm like, 'Oh boy.' Because at the time we were working on a personal space… I asked the woman, I said 'Are you okay with this?' " he told PEOPLE in October 2025. "And she goes, 'You have no idea how much I need this.' I'm like, 'Great, who are you? And she had [a] poncho on and I didn't know she was this beautiful siren. And she takes the poncho off, and she goes, 'I'm Nichole, I live around here.' "
He continued, "I think I thought I had a notion of what love looked like and I didn't. I didn't have a clue until Maxie came along. He introduced me to love and he introduced me to my wife."
John and Nichole have since welcomed two daughters together: Billie and Kate.
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